Hundreds of roadways are closed in North Carolina, including parts of two interstates, snarling delivery routes and posing a challenge for the logistics community as it works to get supplies to trapped residents. Hurricane Helene hit Florida on Thursday and crawled along the Southeast, devastating western North Carolina. The region was inundated by heavy rain — up to 30 inches in some parts — which caused severe flooding, wiping away roadways and downing power lines in that part of the state. Some residents in the mountains were stranded.

More than 100 people across six states have died from Helene, officials said. “This is unprecedented,” said Ben Greenberg, president and CEO of North Carolina Trucking Association.

The state trucking organization is coordinating supply drops, but “it’s simply not enough,” Greenberg said. The infrastructure woes paired with the looming port strike will further complicate efforts to get supplies to those who need them most, he said.

Although Greenberg said he has not received reports yet from association members who were impacted by the catastrophe, he said he is “100% confident” some member companies and distribution centers were affected by the storm.

Kathy Fulton, the executive director of nonprofit American Logistics Aid Network, said the situation in North Carolina was desperate. Over 400,000 homes and businesses were without power on Monday, according to PowerOutage.us. The nonprofit is...